Circadian disruption induced by light at night accelerates aging and promotes

tumorigenesis in rats

Irina A. Vinogradova, Vladimir N. Anisimov, Andrey V. Bukalev, Anna V.Semenchenko, Mark A. Zabezhinski

Abstract: We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural death. We found that exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis, shortened life span both in male and females rats as compared to the standard LD regimen. We conclude that circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. This observation supports the conclusion of the International Agency Research on Cancer that shift­work that involves circadian disruption is probably carcinogenic to humans.  

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PHYSIOLOGICAL DATA VARIATION IN RABBITS UNDER EXTREME ENVIRONMENTAL CONDITIONS (MAGNETIC STORM)

Sergej M. Chibisov, Franz Halberg, Marya Ragulskaya V., Germaine Cornélissen, Salvador Sánchez-de la Peña

Abstract: Article is dedicated to experimental study of chronostructure of rhythms of various parameters of cardiovascular system activity and their changes under influence of environmental factors. It is shown, that reaction of chronostructure of heart to the stimuli like fluctuations of a geomagnetic field is monotypical and it is a specific adaptive stress. The problem of influence of the Earth geomagnetic field distortion on the chronostructure of morphofunctional conditions of parameters of heart is discussed…   

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